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The relevance of the study is due to the lack of data on the cortical mechanisms of regulation of the activity of the antioxidant defense system in the body of dogs. In this regard, this article is aimed at revealing the specifics of the activity of key enzymes of the system of antioxidant protection of the blood of dogs with various types of higher nervous activity under the influence of short-term food deprivation. It was shown that short-term food deprivation in dogs caused a stressful state, which was accompanied not only by a change in the behavior of the animals, but also reflected the state of the enzymatic link of the antioxidant defense system in their body. In particular, a significant effect of short-term food deprivation on the activity of catalase in dog blood erythrocytes was established (F = 13.7 > FU = 4.15; p < 0.001). We note the increase in the influence of the force of nervous processes on the activity of catalase in the blood of dogs during the experiment from – gh²ᵪ = 0.20 (р < 0.05) in the intact state, to the indicator – гх²ᵪ = 0.68 (р < 0.001) by the third day of research. Also, under the influence of food deprivation, direct connections of the strength and balance of nervous processes with the activity of this enzyme appear (r = 0.52–0.78 (р < 0.05–0.001). Under such influence, after one day and three days after the action of the stress factor, the activity of catalase in the blood of dogs with a weak type of higher nervous activity is lower by 3.6–5.8% (P < 0.05) than that of dogs with a strong balanced mobile type of higher nervous activity blood erythrocytes also found a decrease in the activity of the glutathione link of the antioxidant protection system in the blood plasma of dogs, in particular, under the influence of a stress factor, the activity of glutathione reductase during the day in dogs with various types of higher nervous activity decreases by 11.6–16.9%, respectively (р < 0, 05–0.01), the activity of glutathione reductase also decreases. Prospects for further research consist in the development of new methods for the correction of substance metabolism based on the use of nanoaquachelates of biogenic metals, taking into account the individual characteristics of the dog’s body.

 

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